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Article

Hot-Spot-Specific Probe (HSSP) for Rapid and Accurate Detection of KRAS Mutations in Colorectal Cancer.

Biosensors - 4 Aug 2022

Lee Hyo Joo, Koo Bonhan, Jang Yoon Ok, Liu Huifang, Dao Thuy Nguyen Thi, Lim Seok-Byung, Shin Yong

Abstract excerpt

Detection of oncogene mutations has significance for early diagnosis, customized treatment, treatment progression, and drug resistance monitoring. Here, we introduce a rapid, sensitive, and specific mutation detection assay based on the hot-spot-specific probe (HSSP), with improved clinical utility compared to conventional technologies. We designed HSSP to recognize KRAS mutations in the DNA of colorectal cancer...

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PMID: 36004993
DOI: 10.3390/bios12080597
PMCID: PMC9406089

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