Article
An oligonucleotide-tagged microarray for routine diagnostics of colon cancer by genotyping KRAS mutations.
International journal of oncology - 1 Oct 2014
Liu Yuliang, Gudnason Haukur, Li Yi-Ping, Bang Dang Duong, Wolff Anders
Abstract excerpt
Colorectal cancer (CRC) is one of the most prevalent types of cancer, causing significant morbidity and mortality worldwide. CRC is curable if diagnosed at an early stage. Mutations in the oncogene KRAS play a critical role in early development of CRC. Detection of activated KRAS is of diagnostic and therapeutic importance. In this study, KRAS gene fragments containing mutations in codon 12 were amplified by...
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