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Article

Somatic selection distinguishes oncogenes and tumor suppressor genes.

Bioinformatics (Oxford, England) - 1 Mar 2020

Chandrashekar Pramod, Ahmadinejad Navid, Wang Junwen, Sekulic Aleksandar, Egan Jan B, Asmann Yan W, Kumar Sudhir, Maley Carlo, Liu Li

Abstract excerpt

MOTIVATION: Functions of cancer driver genes vary substantially across tissues and organs. Distinguishing passenger genes, oncogenes (OGs) and tumor-suppressor genes (TSGs) for each cancer type is critical for understanding tumor biology and identifying clinically actionable targets. Although many computational tools are available to predict putative cancer driver genes, resources for context-aware...

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Identifiers

PMID: 32176769
DOI: 10.1093/bioinformatics/btz851
PMCID: PMC7703750

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