Identification of cancer mini-drivers by deciphering selective landscape in the cancer genome.

Abstract excerpt

Cancer development is driven by somatic evolution and clonal selection. However, traditional selective pressure analysis methods have treated all sites within a gene equally, such a gene-level model oversimplifies the complexity of cancer evolution. In this study, we introduced CN/CS-calculator, a novel site-specific method that can capture selective pressures acting across different gene sites. By deciphering...

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