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Article

Extracellular matrix regulation of stress response genes during larval development in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 4 Nov 2022

Chandler Luke M, Choe Keith P

Abstract excerpt

Mutation or loss of 6 extracellular matrix collagen genes disrupts annular furrows in adult C. elegans cuticles, causes a wide "Dumpy" body morphology, and activates osmotic, detoxification, and antimicrobial defense genes. High environmental osmolarity reduces internal turgor pressure, physically distorts the epidermis, and activates the same stress responses. Collagen gene mutations that cause Dumpy without...

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Identifiers

PMID: 36000892
DOI: 10.1093/g3journal/jkac221
PMCID: PMC9635657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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