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Article

Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans

4 Jan 2024

Abstract excerpt

Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing dysfunctional ECM could potentially prevent age-related pathologies. Interventions promoting longevity also impact ECM gene expression. However, the role of ECM composition changes in healthy aging remains unclear. Here we perform proteomics and in-vivo monitoring to systematically investigate ECM composition (matreotype) during...

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PMID: 38177158
DOI: 10.1038/s41467-023-44409-2

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