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Article

Specific collagens maintain the cuticle permeability barrier in Caenorhabditis elegans.

Genetics - 31 Mar 2021

Sandhu Anjali, Badal Divakar, Sheokand Riya, Tyagi Shalini, Singh Varsha

Abstract excerpt

Collagen-enriched cuticle forms the outermost layer of skin in nematode Caenorhabditis elegans. The nematode's genome encodes 177 collagens, but little is known about their role in maintaining the structure or barrier function of the cuticle. In this study, we found six permeability determining (PD) collagens. Loss of any of these PD collagens-DPY-2, DPY-3, DPY-7, DPY-8, DPY-9, and DPY-10-led to enhanced...

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Identifiers

PMID: 33789349
DOI: 10.1093/genetics/iyaa047
PMCID: PMC8045729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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