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Article

Extracellular leucine-rich repeat proteins are required to organize the apical extracellular matrix and maintain epithelial junction integrity in C. elegans.

Development (Cambridge, England) - 1 Mar 2012

Mancuso Vincent P, Parry Jean M, Storer Luke, Poggioli Corey, Nguyen Ken C Q, Hall David H, Sundaram Meera V

Abstract excerpt

Epithelial cells are linked by apicolateral junctions that are essential for tissue integrity. Epithelial cells also secrete a specialized apical extracellular matrix (ECM) that serves as a protective barrier. Some components of the apical ECM, such as mucins, can influence epithelial junction remodeling and disassembly during epithelial-to-mesenchymal transition (EMT). However, the molecular composition and...

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Identifiers

PMID: 22278925
DOI: 10.1242/dev.075135
PMCID: PMC3274359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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