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DNA methylome and single-cell transcriptome analyses reveal CDA as a potential druggable target for ALK inhibitor-resistant lung cancer therapy.

Experimental & molecular medicine - 1 Aug 2022

Heo Haejeong, Kim Jong-Hwan, Lim Hyun Jung, Kim Jeong-Hwan, Kim Miso, Koh Jaemoon, Im Joo-Young, Kim Bo-Kyung, Won Misun, Park Ji-Hwan, Shin Yang-Ji, Yun Mi Ran, Cho Byoung Chul, Kim Yong Sung, Kim Seon-Young, Kim Mirang

Abstract excerpt

Acquired resistance to inhibitors of anaplastic lymphoma kinase (ALK) is a major clinical challenge for ALK fusion-positive non-small-cell lung cancer (NSCLC). In the absence of secondary ALK mutations, epigenetic reprogramming is one of the main mechanisms of drug resistance, as it leads to phenotype switching that occurs during the epithelial-to-mesenchymal transition (EMT). Although drug-induced epigenetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35999456
DOI: 10.1038/s12276-022-00836-7
PMCID: PMC9440127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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