Article

Targeting CDA-Directed Metabolism With 5-Formyl-2'-Deoxycytidine For ALK Inhibitor–Resistant Lung Cancer Therapy

2021-12-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Acquired resistance to inhibitors of anaplastic lymphoma kinase (ALK) is a major clinical challenge for ALK fusion–positive non-small-cell lung cancer (NSCLC). In the absence of secondary ALK mutations, epigenetic reprogramming is one of the main mechanisms of drug resistance as it leads to phenotype switching that occurs during the epithelial-to-mesenchymal tra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce8b1e0e-7303-5b73-8e41-3bcb31346a11
DOI: 10.21203/rs.3.rs-1110449/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting CDA-Directed Metabolism With 5-Formyl-2'-Deoxycytidine For ALK Inhibitor–Resistant Lung Cancer TherapyDOI 10.21203/rs.3.rs-1110449/v1Read

DNA methylome and single-cell transcriptome analyses reveal CDA as a potential druggable target for ALK inhibitor-resistant lung cancer therapy.Semantic proximity Read

Identification of genetic variations associated with drug resistance in non-small cell lung cancer patients undergoing systemic treatment.Semantic proximity Read

Resistance profiles of anaplastic lymphoma kinase tyrosine kinase inhibitors in advanced non-small-cell lung cancer: a multicenter study using targeted next-generation sequencing.Semantic proximity Read

Epigenetic enzyme mutations as mediators of anti-cancer drug resistance.Semantic proximity Read

DNA methylation-driven EMT is a common mechanism of resistance to various therapeutic agents in cancerSemantic proximity Read

Genomic Aberrations in Crizotinib Resistant Lung Adenocarcinoma Samples Identified by Transcriptome Sequencing.Semantic proximity Read

Transcriptomics-Guided Personalized Prescription of Targeted Therapeutics for Metastatic ALK-Positive Lung Cancer Case Following Recurrence on ALK InhibitorsSemantic proximity Read

Acquired Resistance to Decitabine Associated with the Deoxycytidine Kinase A180P Mutation: Implications for the Order of Hypomethylating Agents in Myeloid Malignancies TreatmentSemantic proximity Read

APOBEC3A drives acquired resistance to targeted therapies in non-small cell lung cancerSemantic proximity Read

Decitabine-induced DNA methylation-mediated transcriptomic reprogramming in human breast cancer cell lines; the impact of DCK overexpressionSemantic proximity Read

The Emerging Role of Cytidine Deaminase in Human Diseases: A New Opportunity for Therapy?Semantic proximity Read

PHGDH inhibition overcomes dabrafenib resistance through metabolic rewiring in BRAF V600E anaplastic thyroid carcinomaSemantic proximity Read