Article
Expanded Circulating Tumor Cells from a Patient with ALK-Positive Lung Cancer Present with EML4-ALK Rearrangement Along with Resistance Mutation and Enable Drug Sensitivity Testing: A Case Study.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Feb 2017
Zhang Zhuo, Shiratsuchi Hiroe, Palanisamy Nallasivam, Nagrath Sunitha, Ramnath Nithya
Abstract excerpt
The emergence of liquid biopsy using circulating tumor cells (CTCs) as a resource to identify genomic alterations in cancer presents new opportunities for diagnosis, therapy, and surveillance. We identified EML4-ALK gene rearrangement in expanded CTCs from a patient with ALK-positive lung adenocarcinoma. At the time of radiographic progression, CTCs obtained from the patient revealed a drug resistance mutation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.