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Article

Targeting METTL3 enhances the chemosensitivity of non-small cell lung cancer cells by decreasing ABCC2 expression in an m6A-YTHDF1-dependent manner

1 Jan 2024

Abstract excerpt

Patients with non-small cell lung cancer (NSCLC) are easily resistant to first-line chemotherapy with paclitaxel (PTX) or carboplatin (CBP).N 6 -methyladenosine (m 6 A) methyltransferase-like 3 (METTL3) has crucial functions in m 6 A modification and tumorigenesis.However, its role in chemoresistance of NSCLC is still elusive.Here, we demonstrated that METTL3 inhibitor STM2457 significantly reduced the IC50...

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PMID: 39309428
DOI: 10.7150/ijbs.97425

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