Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA methylation-driven EMT is a common mechanism of resistance to various therapeutic agents in cancer

14 Feb 2020

Abstract excerpt

BACKGROUND: Overcoming therapeutic resistance is one of the major hurdles in cancer care. One mechanism contributing to therapeutic resistance is a process in which epithelial cells switch to a mesenchymal state (epithelial-to-mesenchymal transition or EMT). The precise mechanisms driving EMT-mediated therapeutic resistance have, however, not been elucidated. RESULTS: Here, we study ten cell line pairs, for which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Epigenetics and DNA Methylation
Share to Immune cells in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32059745
DOI: 10.1186/s13148-020-0821-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA methylation-driven EMT is a common mechanism of resistance to various therapeutic agents in cancerPMID 32059745Read ↗

Coordinated activation of DNMT3a and TET2 in cancer stem cell-like cells initiates and sustains drug resistance in hepatocellular carcinomaSemantic proximity Read ↗

Liquid biopsy uncovers distinct patterns of DNA methylation and copy number changes in NSCLC patients with different EGFR-TKI resistant mutations.Semantic proximity Read ↗

The paradigm of drug resistance in cancer: an epigenetic perspectiveSemantic proximity Read ↗

The EMT spectrum and therapeutic opportunities.Semantic proximity Read ↗

A human model of epithelial to mesenchymal transition to monitor drug efficacy in hepatocellular carcinoma progression.Semantic proximity Read ↗

The emergence of resistance to targeted cancer therapeutics.Semantic proximity Read ↗

Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer.Semantic proximity Read ↗

Epithelial-to-mesenchymal transition is a resistance mechanism to sequential MET-TKI treatment of MET-amplified EGFR-TKI resistant non-small cell lung cancer cellsSemantic proximity Read ↗

Secrets of Drug Resistance in NSCLC Exposed by New Molecular Definition of EMTSemantic proximity Read ↗

Drug resistance, epigenetics, and tumor cell heterogeneity.Semantic proximity Read ↗

Genomic and Molecular Screenings Identify Different Mechanisms for Acquired Resistance to MET Inhibitors in Lung Cancer Cells.Semantic proximity Read ↗

DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.