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Whole‐genome bisulfite sequencing analysis of circulating tumour DNA for the detection and molecular classification of cancer

1 Aug 2022

Abstract excerpt

BACKGROUND: Cancer cell-specific variation and circulating tumour DNA (ctDNA) methylation are promising biomarkers for non-invasive cancer detection and molecular classification. Nevertheless, the applications of ctDNA to the early detection and screening of cancer remain highly challenging due to the scarcity of cancer cell-specific ctDNA, the low signal-to-noise ratio of DNA variation, and the lack of...

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PMID: 35998020
DOI: 10.1002/ctm2.1014

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