Development of a Novel NGS Methodology for Ultrasensitive Circulating Tumor DNA Detection as a Tool for Early-Stage Breast Cancer Diagnosis.

doi:10.3390/ijms24010146

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Article

Development of a Novel NGS Methodology for Ultrasensitive Circulating Tumor DNA Detection as a Tool for Early-Stage Breast Cancer Diagnosis.

International journal of molecular sciences - 21 Dec 2022

Jiménez-Rodríguez Begoña, Alba-Bernal Alfonso, López-López Esperanza, Quirós-Ortega María Elena, Carbajosa Guillermo, Garrido-Aranda Alicia, Álvarez Martina, Godoy-Ortiz Ana, Queipo-Ortuño María Isabel, Vicioso Luis, Díaz-Córdoba Gema, Roldán-Díaz María Dunia, Velasco-Suelto Jesús, Hernando Cristina, Bermejo Begoña, Julve-Parreño Ana, Lluch Ana, Pascual Javier, Comino-Méndez Iñaki, Alba Emilio

Abstract excerpt

Breast cancer (BC) is the most prevalent cancer in women. While usually detected when localized, invasive procedures are still required for diagnosis. Herein, we developed a novel ultrasensitive pipeline to detect circulating tumor DNA (ctDNA) in a series of 75 plasma samples from localized BC patients prior to any medical intervention. We first performed a tumor-informed analysis to correlate the mutations found...

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Identifiers

PMID: 36613590
DOI: 10.3390/ijms24010146
PMCID: PMC9820510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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