Article

Development of a novel NGS methodology for ultrasensitive circulating tumour DNA detection as a tool for early-stage breast cancer diagnosis

2022-11-10

Abstract excerpt

BACKGROUND Breast cancer (BC) is the most prevalent cancer in women. While usually detected when localized, invasive procedures are still required for diagnosis. METHODS Herein, we developed a novel ultrasensitive pipeline to detect circulating tumour DNA (ctDNA) in a series of 75 plasma samples from localized BC patients prior to any medical intervention. We first performed a tumour-informed analysis to correla...

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Literature Corpus work: a67f3608-5564-5bdc-a403-6f2c28ea33e7
DOI: 10.21203/rs.3.rs-2246067/v1

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