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Impact of schizophrenia-associated risk genes on brain functional networks and executive deficits: a study of individuals with schizophrenia and genetic high risk.

Psychological medicine - 20 Aug 2025

Sun Ting, Zhu Yue, Zhao Pengfei, Zhao Wenhui, Liu Linzi, Tang Lili, Li Mengxue, Xu Yixiao, Wang Pengshuo, Zhang Yifan, Zhou Yuning, Zhou Yifang, Kang Jujiao, Gong Xiaohong, Wang Fei, Tang Yanqing

Abstract excerpt

BACKGROUND: Schizophrenia (SCZ) and genetic high-risk (GHR) individuals exhibit deficits in brain functional networks and cognitive function, potentially impacted by SCZ risk genes. This study aims to delineate these impairments in SCZ and GHR individuals, and further explore how risk genes affect brain networks and executive function. METHODS: A total sample size of 292 participants (100 SCZ, 68 GHR, and 124...

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Identifiers

PMID: 40831310
DOI: 10.1017/S0033291725101177
PMCID: PMC12404332

Genes

GHR

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