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Article

Polygenic risk scores in imaging genetics: Usefulness and applications.

Journal of psychopharmacology (Oxford, England) - 1 Aug 2015

Dima Danai, Breen Gerome

Abstract excerpt

Genetic factors account for up to 80% of the liability for schizophrenia and bipolar disorder. Genome-wide association studies (GWAS) have successfully identified several single nucleotide polymorphisms (SNPs) and genes associated with increased risk for both disorders. Single SNP analyses alone do not address the overall genomic or polygenic architecture of psychiatric disorders as the amount of phenotypic...

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PMID: 25944849
DOI: 10.1177/0269881115584470

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