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Article

RNA sequencing of intestinal mucosa reveals novel pathways functionally linked to celiac disease pathogenesis

18 Apr 2019

Abstract excerpt

BACKGROUND & AIMS: The early steps in the pathophysiology of celiac disease (CD) leading to loss of tolerance to gluten are poorly described. Our aim was to use RNA sequencing of duodenal biopsies in patients with active CD, CD in remission, and non-CD controls to gain insight into CD pathophysiology, identify additional genetic signatures linked to CD, and possibly uncover targets for future therapeutic agents....

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PMID: 30998704
DOI: 10.1371/journal.pone.0215132

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