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Single cell transcriptome sequencing indicates the cellular heterogeneity of small intestine tissue in celiac disease

10 Apr 2025

Abstract excerpt

Celiac disease (CeD) is an autoimmune small intestinal disease caused by gluten protein ingestion by genetically susceptible individuals. Genome-wide association studies and transcriptomic data have limited capacity to capture intercellular genetic variations. We aimed to construct a single cell transcriptome spectrum, analyze the immune microenvironment and cellular heterogeneity, discover disease-related...

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PMID: 40216823
DOI: 10.1038/s41598-025-90300-z

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