Article

Proteomic analysis of the TDP-43-associated insoluble fraction from NEFH-TDP-43 mouse brain suggests sustained stress granule formation, CLUH granule recruitment and impaired mitochondrial metabolism

2024-05-23

Abstract excerpt

Cytoplasmic accumulation and aggregation of TDP-43 is a hallmark of ∼97% of ALS cases. Formation of TDP-43 insoluble aggregates is suggested to either directly or indirectly cause motor neuron loss and progressive neuromuscular degeneration, although how this occurs is not precisely understood. Cytoplasmic TDP-43 is observed in stress granules (SG). SGs are ribonucleoprotein (RNP) complexes formed during stress co...

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Literature Corpus work: 5eeedd5e-93d7-5b9d-a41d-5aa7a1ffeff8
DOI: 10.1101/2024.05.23.595607

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Proteomic analysis of the TDP-43-associated insoluble fraction from NEFH-TDP-43 mouse brain suggests sustained stress granule formation, CLUH granule recruitment and impaired mitochondrial metabolismDOI 10.1101/2024.05.23.595607Read

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