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Article

ALS-linked mutations enlarge TDP-43-enriched neuronal RNA granules in the dendritic arbor.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 19 Mar 2014

Liu-Yesucevitz Liqun, Lin Amy Y, Ebata Atsushi, Boon Joon Y, Reid Whitney, Xu Ya-Fei, Kobrin Kendra, Murphy George J, Petrucelli Leonard, Wolozin Benjamin

Abstract excerpt

Trans-activating response region (TAR) DNA-binding protein of 43 kDa (TDP-43) is an RNA-binding protein that is mutated in familial amyotrophic lateral sclerosis (ALS). Disease-linked mutations in TDP-43 increase the tendency of TDP-43 to aggregate, leading to a corresponding increase in formation of stress granules, cytoplasmic protein/RNA complexes that form in response to stress. Although the field has focused...

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Identifiers

PMID: 24647938
DOI: 10.1523/JNEUROSCI.2350-13.2014
PMCID: PMC3960463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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