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Article

Deubiquitinase USP19 extends the residual enzymatic activity of phenylalanine hydroxylase variants.

Scientific reports - 20 Aug 2022

Sarodaya Neha, Tyagi Apoorvi, Kim Hyun-Jin, Kang Ju-Seop, Singh Vijai, Hong Seok-Ho, Kim Woo Jin, Kim Kye-Seong, Ramakrishna Suresh

Abstract excerpt

Phenylalanine hydroxylase (PAH) is a key enzyme in mammals that maintains the phenylalanine (Phe) concentration at an appropriate physiological level. Some genetic mutations in the PAH gene lead to destabilization of the PAH enzyme, leading to phenylketonuria (PKU). Destabilized PAH variants can have a certain amount of residual enzymatic activity that is sufficient for metabolism of Phe. However, accelerated...

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Identifiers

PMID: 35987969
DOI: 10.1038/s41598-022-18656-0
PMCID: PMC9392723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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