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Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics

15 Jun 2020

Abstract excerpt

Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating and deubiquitinating enzymes (DUBs) have been widely elucidated. The ubiquitination of proteins regulates many aspects of cellular functions such as protein degradation and localization, and also modifies protein-protein interactions. DUBs cleave the attached ubiquitin moieties from substrates and thereby reverse the process...

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PMID: 32549302
DOI: 10.3390/cancers12061579

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