Article
Deubiquitinases in cancer: new functions and therapeutic options.
Oncogene - 10 May 2012
Fraile J M, Quesada V, Rodríguez D, Freije J M P, López-Otín C
Abstract excerpt
Deubiquitinases (DUBs) have fundamental roles in the ubiquitin system through their ability to specifically deconjugate ubiquitin from targeted proteins. The human genome encodes at least 98 DUBs, which can be grouped into 6 families, reflecting the need for specificity in their function. The activity of these enzymes affects the turnover rate, activation, recycling and localization of multiple proteins, which in...
Topics
- Antineoplastic Agents
- Cell Cycle
- Chromatin Assembly and Disassembly
- Cysteine Proteinase Inhibitors
- DNA Damage
- Endopeptidases
- Humans
- Molecular Targeted Therapy
- Mutation
- Neoplasms
- Proteasome Inhibitors