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Article

Deubiquitinases in cancer: new functions and therapeutic options.

Oncogene - 10 May 2012

Fraile J M, Quesada V, Rodríguez D, Freije J M P, López-Otín C

Abstract excerpt

Deubiquitinases (DUBs) have fundamental roles in the ubiquitin system through their ability to specifically deconjugate ubiquitin from targeted proteins. The human genome encodes at least 98 DUBs, which can be grouped into 6 families, reflecting the need for specificity in their function. The activity of these enzymes affects the turnover rate, activation, recycling and localization of multiple proteins, which in...

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Identifiers

PMID: 21996736
DOI: 10.1038/onc.2011.443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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