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Deubiquitinases as novel therapeutic targets for diseases

1 Dec 2024

Abstract excerpt

Deubiquitinating enzymes (DUBs) regulate substrate ubiquitination by removing ubiquitin or cleaving within ubiquitin chains, thereby maintaining cellular homeostasis. Approximately 100 DUBs in humans counteract E3 ubiquitin ligases, finely balancing ubiquitination and deubiquitination processes to maintain cellular proteostasis and respond to various stimuli and stresses. Given their role in modulating...

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PMID: 39678489
DOI: 10.1002/mco2.70036

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