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Article

Deubiquitylases From Genes to Organism

1 Jul 2013

Abstract excerpt

Ubiquitylation is a major posttranslational modification that controls most complex aspects of cell physiology. It is reversed through the action of a large family of deubiquitylating enzymes (DUBs) that are emerging as attractive therapeutic targets for a number of disease conditions. Here, we provide a comprehensive analysis of the complement of human DUBs, indicating structural motifs, typical cellular copy...

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PMID: 23899565
DOI: 10.1152/physrev.00002.2013

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