Article
Additive effect of multiple genetic variants on the risk of coronary artery disease.
Revista espanola de cardiologia - 1 Aug 2010
Lluís-Ganella Carla, Lucas Gavin, Subirana Isaac, Sentí Mariano, Jimenez-Conde Jordi, Marrugat Jaume, Tomás Marta, Elosua Roberto
Abstract excerpt
INTRODUCTION AND OBJECTIVES: Coronary artery disease (CAD) has a substantial genetic component and, in recent years, a number of genetic variants associated with the disease have been identified. The objective of this study was to evaluate the magnitude of the association between a genetic risk score, which is based on the accumulated number of risk alleles in all genetic variants of interest, and the presence of...
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