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Interaction between genetics and smoking in determining risk of coronary artery diseases.

Genetic epidemiology - 1 Apr 2022

Huang Yunfeng, Hui Qin, Gwinn Marta, Hu Yi-Juan, Quyyumi Arshed A, Vaccarino Viola, Sun Yan V

Abstract excerpt

Coronary artery disease (CAD) is a preeminent cause of death, and smoking is a strong risk factor for CAD. Genetic factors contribute to the development of CAD, but the interplay between genetic predisposition and smoking history in CAD remains unclear. Using data from the UK Biobank, we constructed several genetic risk scores (GRSs) based on known CAD loci and assessed their interactions with smoking for the...

Topics

Coronary Artery Disease
Genetic Predisposition to Disease
Humans
Models, Genetic
Risk Factors
Smoking

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35170807
DOI: 10.1002/gepi.22446
PMCID: PMC9086149

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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