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Article

The interplay of genetics and modifiable risk in atherosclerosis.

Atherosclerosis - 1 Jun 2026

Schunkert Heribert

Abstract excerpt

Genetic disposition accounts for about half of the risk to develop coronary artery disease (CAD). Yet, Mendel's Laws fail to explain its high prevalence. The conceptual dilemma was resolved by the common-disease-common-variant hypothesis, which proposes that common diseases like CAD are caused by multiple common genetic variants. Mapping of the human genome and consecutive genomewide association studies verified...

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Source

Identifiers

PMID: 42178200
DOI: 10.1016/j.atherosclerosis.2026.120727

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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