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Article

Abnormal TNS3 gene methylation in patients with congenital scoliosis

20 Aug 2022

Abstract excerpt

BACKGROUND: Congenital scoliosis (CS) is a congenital deformity of the spine resulting from abnormal and asymmetrical development of vertebral bodies during pregnancy. However, the etiology and mechanism of CS remain unclear. Epigenetics is the study of heritable variations in gene expression outside of changes in nucleotide sequence. Among these, DNA methylation was described first and is the most characteristic...

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PMID: 35987623
DOI: 10.1186/s12891-022-05730-x

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