Article
A twin‑pair analysis indicates congenital scoliosis is associated with allele‑specific methylation in the SVIL gene.
Molecular medicine reports - 1 Sept 2020
Zhang Zhifa, Chen Yongjun, Wu Yuezhou, Hao Yongyu, Zhao Xuelin, Wang Xiangyu, Wang Yan, Xi Yanhai, Zhang Xuesong
Abstract excerpt
Congenital scoliosis (CS) is a congenital disease resulting in abnormal vertebral development. Several studies have indicated that both genetic and environmental factors during pregnancy increase the risk of CS development. However, the exact mechanisms underlying CS pathogenesis remain unknown. To address this issue, both genetic (by whole‑exome sequencing) and epigenetic (by methylated DNA immunoprecipitation...
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