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Article

Quantitative evaluation of the relationship between COMP promoter methylation and the susceptibility and curve progression of adolescent idiopathic scoliosis.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society - 1 Feb 2018

Mao Sai-Hu, Qian Bang-Ping, Shi Benlong, Zhu Ze-Zhang, Qiu Yong

Abstract excerpt

PURPOSE: The cartilage oligomeric matrix protein (COMP) was reported to be down-regulated in adolescent idiopathic scoliosis (AIS). The purposes of the study were to evaluate the roles of COMP promoter methylation on the abnormal gene expression and the epigenetic phenotype in AIS. METHODS: DNA samples of 50 AIS patients and 50 healthy controls were analyzed. Five CpG sites of COMP gene were amplified and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28951969
DOI: 10.1007/s00586-017-5309-y

Genes

COMP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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