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Abnormal PITX1 gene methylation in adolescent idiopathic scoliosis: a pilot study

9 May 2018

Abstract excerpt

BACKGROUND: The gene of pituitary homeobox 1 (PITX1) has been reported to be down-regulated in adolescent idiopathic scoliosis (AIS), of which the cause has not been well addressed. The abnormal DNA methylation was recently assumed to be an important mechanism for the down-regulated genes expression. However, the association between PITX1 promoter methylation and the etiology of AIS was not clear. METHODS: The...

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PMID: 29743058
DOI: 10.1186/s12891-018-2054-2

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