Prognostic significance of pathogenic variants in BRCA1, BRCA2, ATM and PALB2 genes in men undergoing hormonal therapy for advanced prostate cancer.

doi:10.1038/s41416-022-01915-2

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Prognostic significance of pathogenic variants in BRCA1, BRCA2, ATM and PALB2 genes in men undergoing hormonal therapy for advanced prostate cancer.

British journal of cancer - 1 Nov 2022

Kimura Hiroko, Mizuno Kei, Shiota Masaki, Narita Shintaro, Terada Naoki, Fujimoto Naohiro, Ogura Keiji, Hatano Shotaro, Iwasaki Yusuke, Hakozaki Nozomi, Ishitoya Satoshi, Sumiyoshi Takayuki, Goto Takayuki, Kobayashi Takashi, Nakagawa Hidewaki, Kamoto Toshiyuki, Eto Masatoshi, Habuchi Tomonori, Ogawa Osamu, Momozawa Yukihide, Akamatsu Shusuke

Abstract excerpt

BACKGROUND: The prognostic significance of germline variants in homologous recombination repair genes in advanced prostate cancer (PCa), especially with regard to hormonal therapy, remains controversial. METHODS: Germline DNA from 549 Japanese men with metastatic and/or castration-resistant PCa was sequenced for 27 cancer-predisposing genes. The associations between pathogenic variants and clinical outcomes were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA1 Protein

Share to BRCA2 Protein

Share to Fanconi Anemia Complementation Group N Protein

Share to Genes, BRCA2

Share to Germ-Line Mutation

Share to Prognosis

Share to Prostatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 35986085
DOI: 10.1038/s41416-022-01915-2
PMCID: PMC9596487

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prognostic significance of pathogenic variants in BRCA1, BRCA2, ATM and PALB2 genes in men undergoing hormonal therapy for advanced prostate cancer.PMID 35986085Read ↗

Prognostic value of genomic mutations in metastatic prostate cancerSemantic proximity Read ↗

[Homologous recombination repair gene variants in hormone-sensitive prostate cancer].Semantic proximity Read ↗

Hereditary Prostate Cancer: Genes Related, Target Therapy and PreventionSemantic proximity Read ↗

Germline Testing for Prostate Cancer Patients: Evidence-Based Evaluation of Genes Recommended by NCCN Guidelines.Semantic proximity Read ↗

Germline Pathogenic Variants in 7636 Japanese Patients With Prostate Cancer and 12 366 ControlsSemantic proximity Read ↗

Contribution of Inherited DNA-Repair Gene Mutations to Hormone-Sensitive and Castrate-Resistant Metastatic Prostate Cancer and Implications for Clinical OutcomeSemantic proximity Read ↗

Homologous recombination repair gene mutations in Chinese localized and locally advanced prostate cancer patients.Semantic proximity Read ↗

Observed evidence for guideline-recommended genes in predicting prostate cancer risk from a large population-based cohort.Semantic proximity Read ↗

Germline DNA-repair Gene Mutations and Outcomes in Men with Metastatic Castration-resistant Prostate Cancer Receiving First-line Abiraterone and Enzalutamide.Semantic proximity Read ↗

Germline Mutations in DNA Repair Genes in Patients With Metastatic Castration-resistant Prostate Cancer.Semantic proximity Read ↗

The prevalence of gene mutations in homologous recombination repair pathways in Japanese patients with metastatic castration-resistant prostate cancer in real-world clinical practice: The multi-institutional observational ZENSHIN study.Semantic proximity Read ↗

Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.