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Article

Germline DNA-repair Gene Mutations and Outcomes in Men with Metastatic Castration-resistant Prostate Cancer Receiving First-line Abiraterone and Enzalutamide.

European urology - 1 Aug 2018

Antonarakis Emmanuel S, Lu Changxue, Luber Brandon, Liang Chao, Wang Hao, Chen Yan, Silberstein John L, Piana Danilo, Lai Zhao, Chen Yidong, Isaacs William B, Luo Jun

Abstract excerpt

BACKGROUND: Inherited DNA-repair gene mutations are more prevalent in men with advanced prostate cancer than previously thought, but their clinical implications are not fully understood. OBJECTIVE: To investigate the clinical significance of germline DNA-repair gene alterations in men with metastatic castration-resistant prostate cancer (mCRPC) receiving next-generation hormonal therapy (NHT), with a particular...

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Identifiers

PMID: 29439820
DOI: 10.1016/j.eururo.2018.01.035
PMCID: PMC6045965

Genes

ATM
BRCA1

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