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Homologous recombination repair gene mutations in Chinese localized and locally advanced prostate cancer patients.

Pathology, research and practice - 1 Aug 2021

Jiang Xingran, Hu Xiumei, Gu Yajuan, Li Yunlong, Jin Mulan, Zhao Hongying, Gao Ruixia, Huang Zhan, Lu Jun

Abstract excerpt

BACKGROUND: Homologous recombination repair gene (HRR) mutations have been proven to be effective biomarkers for PARP inhibitor therapy for metastatic castration resistant prostate cancer. However, the frequency of HRR mutations in patients with localized and locally advanced prostate cancer is still unclear. This study investigated the profile of HRR gene mutations in Chinese localized and locally advanced...

Topics

Aged
Aged, 80 and over
Biomarkers, Tumor
China
Humans
Male
Middle Aged
Mutation
Neoplasm Grading
Prostatectomy
Prostatic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinational DNA Repair

Retrospective Studies

Source

Identifiers

PMID: 34102435
DOI: 10.1016/j.prp.2021.153507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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