Article
The prevalence of gene mutations in homologous recombination repair pathways in Japanese patients with metastatic castration-resistant prostate cancer in real-world clinical practice: The multi-institutional observational ZENSHIN study.
Cancer medicine - 1 Mar 2023
Uemura Hiroji, Oya Mototsugu, Kamoto Toshiyuki, Sugimoto Mikio, Shinozaki Kenta, Morita Kiyomi, Koto Ryo, Takahashi Mai, Nii Masahiro, Shin Eisei, Nonomura Norio
Abstract excerpt
BACKGROUND: Metastatic castration-resistant prostate cancer (mCRPC) is a genetically heterogeneous disease with a poor prognosis. The prevalence of mutations in homologous recombination repair (HRR) pathway genes, including BRCA1/2, as well as treatment patterns and clinical outcomes, are not well characterized among Japanese men with mCRPC. METHODS: This multicenter, noninterventional cohort study enrolled...
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