Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer.

doi:10.1200/JCO.2012.43.1882

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Article

Germline BRCA mutations are associated with higher risk of nodal involvement, distant metastasis, and poor survival outcomes in prostate cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 May 2013

Castro Elena, Goh Chee, Olmos David, Saunders Ed, Leongamornlert Daniel, Tymrakiewicz Malgorzata, Mahmud Nadiya, Dadaev Tokhir, Govindasami Koveela, Guy Michelle, Sawyer Emma, Wilkinson Rosemary, Ardern-Jones Audrey, Ellis Steve, Frost Debra, Peock Susan, Evans D Gareth, Tischkowitz Marc, Cole Trevor, Davidson Rosemarie, Eccles Diana, Brewer Carole, Douglas Fiona, Porteous Mary E, Donaldson Alan, Dorkins Huw, Izatt Louise, Cook Jackie, Hodgson Shirley, Kennedy M John, Side Lucy E, Eason Jacqueline, Murray Alex, Antoniou Antonis C, Easton Douglas F, Kote-Jarai Zsofia, Eeles Rosalind

Abstract excerpt

PURPOSE: To analyze the baseline clinicopathologic characteristics of prostate tumors with germline BRCA1 and BRCA2 (BRCA1/2) mutations and the prognostic value of those mutations on prostate cancer (PCa) outcomes. PATIENTS AND METHODS: This study analyzed the tumor features and outcomes of 2,019 patients with PCa (18 BRCA1 carriers, 61 BRCA2 carriers, and 1,940 noncarriers). The Kaplan-Meier method and Cox...

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Identifiers

PMID: 23569316
DOI: 10.1200/JCO.2012.43.1882
PMCID: PMC3641696

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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