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Article

Thymocyte regulatory variant alters transcription factor binding and protects from type 1 diabetes in infants.

Scientific reports - 19 Aug 2022

Sandholm Niina, Rubio García Arcadio, Pekalski Marcin L, Inshaw Jamie R J, Cutler Antony J, Todd John A

Abstract excerpt

We recently mapped a genetic susceptibility locus on chromosome 6q22.33 for type 1 diabetes (T1D) diagnosed below the age of 7 years between the PTPRK and thymocyte-selection-associated (THEMIS) genes. As the thymus plays a central role in shaping the T cell repertoire, we aimed to identify the most likely causal genetic factors behind this association using thymocyte genomic data. In four thymocyte populations,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35986039
DOI: 10.1038/s41598-022-18296-4
PMCID: PMC9391468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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