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Article

The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.

Diabetologia - 1 Jan 2018

Inshaw Jamie R J, Walker Neil M, Wallace Chris, Bottolo Leonardo, Todd John A

Abstract excerpt

AIMS/HYPOTHESIS: The genetic risk of type 1 diabetes has been extensively studied. However, the genetic determinants of age at diagnosis (AAD) of type 1 diabetes remain relatively unexplained. Identification of AAD genes and pathways could provide insight into the earliest events in the disease process. METHODS: Using ImmunoChip data from 15,696 cases, we aimed to identify regions in the genome associated with...

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PMID: 28983737
DOI: 10.1007/s00125-017-4440-y
PMCID: PMC5719131

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