Article

Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes

2022-09-09

Abstract excerpt

Genome-wide association studies have identified numerous loci with allelic associations to Type 1 Diabetes (T1D) risk. Most disease-associated variants are enriched in regulatory sequences active in lymphoid cell types, suggesting that lymphocyte gene expression is altered in T1D. We assayed gene expression between T1D cases and healthy controls in two autoimmunity-relevant lymphocyte cell types, memory CD4+/CD25+...

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Literature Corpus work: df3eec32-0cea-57de-90fe-4493651f41fc
DOI: 10.1101/2022.09.07.506965

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