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Article

Decoding mutational hotspots in human disease through the gene modules governing thymic regulatory T cells.

Frontiers in immunology - 1 Jan 2024

Raposo Alexandre A S F, Rosmaninho Pedro, Silva Susana L, Paço Susana, Brazão Maria E, Godinho-Santos Ana, Tokunaga-Mizoro Yumie, Nunes-Cabaço Helena, Serra-Caetano Ana, Almeida Afonso R M, Sousa Ana E

Abstract excerpt

Computational strategies to extract meaningful biological information from multiomics data are in great demand for effective clinical use, particularly in complex immune-mediated disorders. Regulatory T cells (Tregs) are essential for immune homeostasis and self-tolerance, controlling inflammatory and autoimmune processes in many diseases with a multigenic basis. Here, we quantify the Transcription Factor (TF)...

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Identifiers

PMID: 39483472
DOI: 10.3389/fimmu.2024.1458581
PMCID: PMC11525063

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