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SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells

19 Aug 2022

Abstract excerpt

Abstract Efforts to cure HIV have focused on reactivating latent proviruses to enable elimination by CD8 + cytotoxic T-cells. Clinical studies of latency reversing agents (LRA) in antiretroviral therapy (ART)-treated individuals have shown increases in HIV transcription, but without reductions in virologic measures, or evidence that HIV-specific CD8 + T-cells were productively engaged. Here, we show that the...

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PMID: 35985993
DOI: 10.1038/s41467-022-32376-z

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