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CD4 + and CD8 + T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment

23 Aug 2024

Abstract excerpt

SARS-CoV-2 infection induces the generation of virus-specific CD4 + and CD8 + effector and memory T cells. However, the contribution of T cells in controlling SARS-CoV-2 during infection is not well understood. Following infection of C57BL/6 mice, SARS-CoV-2–specific CD4 + and CD8 + T cells are recruited to the respiratory tract, and a vast proportion secrete the cytotoxic molecule granzyme B. Using depleting...

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PMID: 39178263
DOI: 10.1126/sciadv.adp2636

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