Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Yin-Yang Dynamics of DNA Methylation Is the Key Regulator for Smooth Muscle Cell Phenotype Switch and Vascular Remodeling.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2017

Zhuang Jianhui, Luan Peipei, Li Hailing, Wang Kai, Zhang Pei, Xu Yawei, Peng Wenhui

Abstract excerpt

OBJECTIVE: DNA methylation plays an important role in chronic diseases such as atherosclerosis, yet the mechanisms are poorly understood. The objective of our study is to indicate the regulatory mechanisms of DNA methylation in vascular smooth muscle cells (VSMCs) and its roles in atherosclerosis. APPROACH AND RESULTS: In ApoE-/- mice fed a Western diet, DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methylcytosine
Share to Aortic Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Azacitidine

Share to Cell Dedifferentiation

Share to Decitabine

Share to Dioxygenases

Share to DNA (Cytosine-5-)-Methyltransferase 1

Share to Vascular Remodeling

Source

Identifiers

PMID: 27879253
DOI: 10.1161/ATVBAHA.116.307923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Yin-Yang Dynamics of DNA Methylation Is the Key Regulator for Smooth Muscle Cell Phenotype Switch and Vascular Remodeling.PMID 27879253Read ↗

Influence of DNA Methylation on Vascular Smooth Muscle Cell Phenotypic Switching.Semantic proximity Read ↗

Role of DNA methylation in cardiovascular diseases.Semantic proximity Read ↗

Epigenetic Control of Vascular Smooth Muscle Cell Function in Atherosclerosis: A Role for DNA Methylation.Semantic proximity Read ↗

DNA Methylation in Atherosclerosis: A New PerspectiveSemantic proximity Read ↗

The Complex Role of Methylation in Regulating Vascular Smooth Muscle Cell Phenotypic States in Vascular Remodeling and Atherosclerosis.Semantic proximity Read ↗

Methyltransferase-like 3-catalysed N6-methyladenosine methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis.Semantic proximity Read ↗

Methyltransferase-like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation.Semantic proximity Read ↗

DNA methylation abnormalities in atherosclerosisSemantic proximity Read ↗

JIB-04, a histone demethylase Jumonji C domain inhibitor, regulates phenotypic switching of vascular smooth muscle cells.Semantic proximity Read ↗

Histone modification of endothelial-mesenchymal transition in cardiovascular diseasesSemantic proximity Read ↗

The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell–monocyte crosstalk and protects against atherosclerosis via the NF-κB pathwaySemantic proximity Read ↗

METTL14 inhibits atherogenesis by epigenetically activating PPAR-α/γ transcription and fatty acid oxidation in VSMCs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.