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Article

Clonal evolution and expansion associated with therapy resistance and relapse of colorectal cancer.

Mutation research. Reviews in mutation research - 1 Jan 2000

S Anupriya, Chakraborty Averi, Patnaik Srinivas

Abstract excerpt

Colorectal cancer (CRC) arises by a continuous process of genetic diversification and clonal evolution. Multiple genes and pathways have a role in tumor initiation and progression. The gradual accumulation of genetic and epigenetic processes leads to the establishment of adenoma and cancer. The important 'driver' mutations in tumor suppressor genes (such as TP53, APC, and SMAD4) and oncogenes (such as KRAS, NRAS,...

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Source

Identifiers

PMID: 36371022
DOI: 10.1016/j.mrrev.2022.108445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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