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Mitochondrial and metabolic dysfunction of peripheral immune cells in multiple sclerosis

20 Jan 2024

Abstract excerpt

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been implicated in the pathogenesis of MS, as studies have shown abnormalities in mitochondrial activities, metabolism, mitochondrial DNA (mtDNA) levels, and mitochondrial morphology in immune cells of individuals with MS. The presence of...

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PMID: 38243312
DOI: 10.1186/s12974-024-03016-8

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