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The Pathophysiological Role of Mitochondrial Oxidative Stress in Rheumatic Diseases

1 Sept 2025

Abstract excerpt

Mitochondria play a crucial role in reactive oxygen species (ROS)-dependent rheumatic diseases, including ankylosing spondylitis, osteoarthritis (OA), systemic lupus erythematosus (SLE) and scleroderma. Mitochondrial DNA (mtDNA), which encodes mitochondrial proteins, is more vulnerable to oxidants compared to nuclear DNA. When mtDNA gets damaged, it leads to mitochondrial dysfunction, such as electron transport...

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PMID: 40917936
DOI: 10.2147/jir.s534574

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