Article
Shared genetic etiology between alcohol dependence and major depressive disorder.
Psychiatric genetics - 1 Aug 2018
Foo Jerome C, Streit Fabian, Treutlein Jens, Ripke Stephan, Witt Stephanie H, Strohmaier Jana, Degenhardt Franziska, Forstner Andreas J, Hoffmann Per, Soyka Michael, Dahmen Norbert, Scherbaum Norbert, Wodarz Norbert, Heilmann-Heimbach Stefanie, Herms Stefan, Cichon Sven, Preuss Ulrich, Gaebel Wolfgang, Ridinger Monika, Hoffmann Sabine, Schulze Thomas G, Maier Wolfgang, Zill Peter, Müller-Myhsok Bertram, Ising Marcus, Lucae Susanne, Nöthen Markus M, Mann Karl, Kiefer Falk, Rietschel Marcella, Frank Josef
Abstract excerpt
The clinical comorbidity of alcohol dependence (AD) and major depressive disorder (MDD) is well established, whereas genetic factors influencing co-occurrence remain unclear. A recent study using polygenic risk scores (PRS) calculated based on the first-wave Psychiatric Genomics Consortium MDD meta-analysis (PGC-MDD1) suggests a modest shared genetic contribution to MDD and AD. Using a (~10 fold) larger discovery...
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